Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats

this study was aimed to evaluate the preventive role of phytic acid on membrane bound enzymes such as sodium potassiumdependent adenosine triphosphatase (Na+ /K+ AtPase), calcium-dependent adenosine triphosphatase (ca2+ AtPase) and magnesiumdependent adenosine triphosphatase (Mg2+ AtPase) and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (IsO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with phytic acid (25 and 50 mg/kg, respectively) for a period of 56 days. After the treatment period, IsO (85 mg/kg) was subcutaneously injected to rats at an interval of 24 h for 2 days. ISO-induced rats showed a significant decrease in the activity of Na+ /K+ AtPase and increase in the activities of ca2+ and Mg2+ ATPase in the heart and a significant (P<0.05) increase in the levels of glycoproteins in serum and the heart were also observed in IsO-induced rats. Pretreatment with phytic acid for a period of 56 days exhibited a significant (P<0.05) effect and altered these biochemical parameters positively in IsO-induced rats. thus, our study shows that phytic acid has cardioprotective role in IsO-induced MI in rats (Int J Biomed Sci 2015; 11 (1): 35-41).